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Several potential mechanisms can be envisioned that would result in CL/P, including failure of prominence growth and/or alignment as well as a failure of fusion of the juxtaposed epithelial seams.
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Failure of facial prominence fusion causes cleft lip and palate (CL/P), a common human birth defect.
Taken together, these data support the idea that the failure of the prominences to fuse and form a normal primary palate is a direct effect of the change in shape.
Failure of the maxillary prominences to fuse with the intermaxillary prominence results in a cleft of the primary palate.
This region of staining, presumably due to apoptosis of the epithelial seam at the fusion point, was not observed in Neo/Null sections, consistent with the failure of fusion between these nasal prominences (supplementary material Fig. S4A,B).
Morphometric analysis of these additional models would determine whether they also involve similar subtle changes in growth trajectories of the prominences, or whether further mechanisms, such as a failure of fusion following normal apposition of the prominences, can also account for this widespread human pathology.
Lateral clefts in CL/P are caused by failure of the lateral nasal and maxillary prominences to fuse and may be either unilateral or bilateral.
The Pirates lost no one of prominence.
Though its success or failure wouldn't necessarily dictate the aquarium's future, Mr. Dohlin said, it is a chance to bump up the aquarium's level of prominence.
It takes work and some measure of prominence.
Women are also gaining positions of prominence in the judiciary.
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