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There is failure of fusion of the dorsal and ventral pancreatic ducts.
Current problems center on the failure of fusion and the morbidity of the autograft donor zone.
The rectovesical ligament is a peritoneal band in women with failure of fusion of the two Müllerian ducts.
This likely represents the persistent ossiculum terminale, which arises as a result of failure of fusion of the secondary ossification centre with the superior aspect of the dens.
A failure of fusion of the vertebral bodies by inadequate bone formation, a so-called 'pseudarthrosis,' can lead to persisting lumbar instability and pain.
Failure of fusion of the maxillary and medial nasal prominences or between the palatal processes results in clefts of varying extent, unilaterally or bilaterally.
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Current knowledge of the mechanisms of tissue fusion throughout development are limited and are of considerable interest as failure of tissue fusion also accounts for other common human birth defects such as cleft palate and neural tube defects (10, 11).
Injection of ofd1 SPL6 MO (4 ng) into tri mutant embryos led to a failure of glomerular fusion in all 27 embryos, displaying a very wide glomerular separation, while 55% of the 82 siblings showed failed fusion.
However, this system is prone to any failure of the fusion center.
However, some patients require reoperation because of complications, failure of bony fusion, persistent pain, or progressive degenerative changes, such as adjacent segment disease.
Taken together, these data demonstrated that TCDD is able to promote growth of hFPECs through AhR-dependent activation of the PI3K/AKT pathway, which may account for the underlying mechanism by which TCDD causes a failure of palatal fusion.
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