The primary endpoint was failure of prophylaxis, defined as the first occurrence of either the need to change the prophylactic regimen or the initiation of intravenous broad-spectrum antibiotics.
aOrgan failure (OF) is defined by at least one point in the nonrespiratory SOFA score.
The main outcome measure was failure of NIPPV defined as subsequent intubation and invasive mechanical ventilation.
Concerning local failure of treatment, defined as recurrence of tumor at the initial treatment sites, resection seems to result in better results than RFA ± resection (Table 1).
The median time to failure of therapy (defined as recurrent presentation with ADHF, hospitalization for ADHF or death) was 30 days [ 13].
Finally, in six studies no improvement was reported in either group, 37 38 39 40 41 42 and one study could not be interpreted in terms of improvement as the main outcome was failure of treatment defined as new or continued bleeding.
Specifically, contractile failure was defined as systolic pump failure or the occurrence of defined patterns (see Methods) of intractable irregular ventricular contractions.
The primary endpoint was the percentage of failure, defined as the occurrence of one or more of the following increase in mWCAs or RR, increase in discomfort (EDIN score), and severe apnea episodes.
The failure probability is then estimated through the union of failure domains defined by each of the linear segments of this polyhedral surface, using second-order bounds.
Finally, the annual probability of failure, defined as the probability of seismic displacement or rocking response exceeding a prescribed limit, is evaluated for different locations in the United States.
