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While this algorithm may appear to be deterministic, the MCS algorithm embedded inside of the algorithm is stochastic and considers the probabilistic failure of available system resources.
The failure of available treatments suggests that the biological mechanisms that underlie metastatic disease are poorly understood.
Much of the early-stage processing of visual inputs occurs within the retinal bipolar cells, and the failure of available vectors to effectively transduce these cells has impacted both basic research and blindness therapies.
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This interest is driven by failures of available antiepileptic drugs in a proportion of epileptic dogs and concerns about possible side effects of antiepileptic drug treatment [ 12, 60– 60].
One of the major reasons for the failure of currently available antiviral therapeutics to achieve a cure of chronic HBV infection is their inability to eradicate or inactivate cccDNA.
For this analysis, serum at the time of diagnosis and at the time of failure was available of seven patients (matched pairs) out of 21 patients who failed.
The limitations of medical therapy to treat end-stage heart failure, the lack of available organs, and the large number of patients who do not qualify for transplantation despite worsening heart failure symptoms all have spurred interest in mechanical circulatory support (MCS).
Among treated and untreated individuals, the advantage of the Alternative strategy compared to the Status Quo was most sensitive to: timing of detecting ART failure, the number of available ART regimens, and the independent effect of ART on AIDS-related mortality.
Threats to effectiveness and sustainability in the paediatric population include morbidity and mortality of primary caregivers due to rising HIV prevalence rates, and although the expectation of poor adherence in this setting leading to widespread "antiretroviral anarchy" has not been met, treatment failure and exhaustion of available regimens are ongoing risks [ 22].
Though the secretary of state for education, Michael Gove, has so far resisted calls for mandatory reporting, the Guardian has learned that his department will be holding a meeting of senior staff at the end of August to discuss what lessons should be learned from the comprehensive failures of all available safeguarding measures at Stanbridge Earls.
That indicates a failure of the science available at the time, he said, rather than a failure of the drug policy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com