Sentence examples for failure of association from inspiring English sources
Our findings add to the understanding of the overall architecture of complex human traits and are consistent with the possibility that GxE interactions are responsible, in part, for the failure of association studies to more fully explain common disease variation.
In the presence of a normal CH1 domain and normal interaction with BiP, failure of association of the light and heavy chains leads to destruction of the unbound heavy chains within the endoplasmic reticulum and these are not secreted.
The common disease-rare variant hypothesis, which suggests a variable subset of multiple rare genetic variants, has greater appeal for complex epilepsy [ 18, 19], especially given the failure of association studies, which work on the premise of the common disease-common variant hypothesis [ 16], to deliver consistent findings.
If some of the associations detected to date in case/control studies of healthy aging and longevity are actually underlain by genotypes with U-shaped curves, the choice of ages for the cases and controls will greatly affect whether an association is detected, and may explain some failures of associations to replicate.
This observation in combination with the lack of telomerase present at telomeres in these cells, lead us to the conclusion that telomeres shrink due to the failure of telomerase association with telomeres.
Ecologic bias or the failure of ecological associations to correspond to biologic effects at the individual level is a concern.
We evaluated occurrence of circuit coagulation, duration of treatment, the impact of circuit clotting on treatment length, risk of retransfusion failure and association of coagulation with treatment and patient characteristics in 309 haemodialysis sessions performed in 94 patients admitted at ICU combining a heparin-grafted dialyzer with a citrate-enriched dialysate.
A major disappointment for most Swedes in 2009 was the failure of the Swedish association football (soccer) team to qualify for the 2010 World Cup in South Africa.
The segregated patterns are indicative of a failure of sister chromatids association (arrows in Figure 4B).
Knockdown of WT CHIP also led to a failure of the SENP3 Hsp90 association.
Genetic heterogeneity in the form of both different disease genes and different alleles (in the same genes) underlying disease risk could account for failure of replication in association studies of common, complex diseases.
