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Finally, we show that for two major chemoeffectors, serine and cysteine, failure of adaptation at concentrations above 1 mM might prevent bacteria from accumulating at toxic concentrations of these amino acids.
A review of evidence suggests that short-term displacement that goes hand-in-hand with loss of life, destruction of property and economic disruption poses significant risks not because it is environmental migration, but because it represents a failure of adaptation to environmental change.
But the primary problem is a failure of adaptation at later ages.
6 51 52 More research is needed to investigate the factors influencing the success or failure of adaptation to LIS.
An alternate mechanism for the failure of adaptation of the CCF in CKCS previously proposed is early closure of bone sutures, similar to craniosynostosis in children [ 24].
Since adaptation involves the careful tuning of functions at every level, from molecule to cell to tissue to organ to overall bodily integration, the failure of adaptation necessarily will take place at all of these levels as well.
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This specialized response reflects the failure of adaptations that normally enable plants to survive over a remarkable temperature range, by mechanisms that are not fully understood.
Ultimately failures of adaptation led to failures of performance.
Frank Miller, the comic book icon turned film-maker, was originally slated to take on the film, but he's no longer in Hollywood's good books after the spectacular critical and commercial failure of his adaptation of The Spirit at the end of 2008.
A failure of adequate adaptation and/or development of the pulmonary lymphatic microvasculature may contribute to the pathomorbidity and mortality seen in established CLD.
The current paradigm holds that cancer is a consequence of internal imperfections of a multi-cellular organism, an evidence of failure of its adaptation mechanisms: the Darwinian evolution does not expect the future and does not plan for it, it is compelled to operate with means that are only available for it at present, "at hand", which makes compromises and restrictions inevitable (Greaves 2007).
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