Sentence examples for failure of activating from inspiring English sources

During the past 15 years of DNA vaccine development, several unanticipated problems have arisen, where the failure of activating potent immune responses in humans has become a major issue.

To explore the causes of failure to activate the rapid response system (RRS).

11 there was a significant rate of failure to activate such a system in the control and intervention hospitals that may have contributed to the equivocal results of the study.

It has been proposed that low levels of active TGF-β1 in the artery wall, resulting from apolipoprotein(a) inhibition of plasminogen activation and failure to activate latent TGF-β1 through plasmin proteolysis, allows endothelial and smooth muscle cell proliferation, leading to intima-medial expansion [ 8, 31].

This phenomenon is related to TGFβ-mediated activation of ERK1/2 and failure to activate p38 in response to TLR.

Most mutations inactivate p53's specific DNA binding, resulting in failure to activate transcription of p53 target genes.

The spermatogenesis arrest in cyclin A1 or Hsp70-2 knock-out mice appears to be the result of a failure to activate Cdc2 by dephosphorylation [29], [30].

Without RANK, the mammary epithelial cells undergo accelerated apoptosis because of a failure to activate the antiapoptotic protein kinase B (PKB/AKT) [ 100].

Single colonies were picked up after selection and used for the analysis of AHR-dependent growth and differentiation by treatment with 100 pM TCDD for 4 hr, followed by removal of the drug and selection for 2 3 days in the presence of 3 μg/mL puromycin, during which time AHR-negative cells died because of their failure to activate the Cyp1a1 promoter.

In experimental renal failure as well, ACE-I therapy attenuated the development of myocardial fibrosis and cardiomyocyte hypertrophy as a result of activating lysosomal proteinases [37].

Failure to activate the apoptotic programme represents an important mode of drug resistance in tumor cells [ 34].