Likewise, pσ1-mediated tolerance could not be established in IL-10−/− mice presumably due to the failure in the generation of FoxP3+ Treg cells [5].
In order to figure out the reason for GATA2 −/− HPC failure in the generation of granulocytes, we examined numbers of genes that were known as critical hematopoietic regulators, particularly those downregulated in H1- GATA2 −/− derived HE and/or HPC (Fig. 4c).
Michael Matise in Alex Joyner's lab had shown that a targeted deletion of Gli2 in mouse embryos (Matise et al, 1998) led to a failure in the generation of the floor plate and the adjacent domain of V3 neuron progenitors: these are the cell types induced by highest concentrations of Shh.
Unfortunately, this rationale provides little specific guidance in areas where it is not possible or desirable to remedy market failures in the generation or distribution of technology by more extensive assignment or enforcement of property rights.
We investigated the mechanism(s) of disruption leading to reproductive failure in the F1 generation by assessing sperm quality, fertilization success in their offspring (F2 generation), gonad development and maturation, and male reproductive behavior in the breeding populations.
When society fails one generation of children, it lays the foundations for similar, even worse failures in the generations to follow.
In complete contrast, life-long exposure (210 dpf) to 5 ng/L EE2 resulted in complete reproductive failure in the F1 generation, with no viability in the eggs at 14 hpf; we found no viable eggs in almost 12,000 spawned (F = 7.6, p < 0.001).
In the failure state, the generation output of the unit is zero and the controllability of the unit is lost.
In the event of a sudden failure in generation or the connection of a large load, the system frequency starts dropping (region OX of Fig. 1) at a rate mainly determined by the summation of the angular momentums of all generators and spinning loads.
2) Two phenotypes of aneuploid cells are described in this manuscript: cytokinesis failure and the generation of lagging chromosomes.
He observes that he is speaking about brown "not in the sense of pigment, necessarily, but brown because mixed, confused, lumped, impure, unpasteurized, as motives are mixed, and the fluids of generation are mixed and emotions are unclear, and the tally of human progress and failure in every generation is mixed, and unaccounted for, missing in plain sight".
