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To study tumor-endothelial interactions, the gold standard co-culture model is transwell culture, which fails to recapitulate the biochemical or physical cues found in tumor niche.
The experiment was conducted in a 2D migration assay model, and therefore fails to recapitulate the native 3D environment encountered by cancer cells.
Thus, these pluripotent cells have a great value in studying human developmental genetic diseases, particularly in cases where the mouse model fails to recapitulate the phenotypes seen in the patients.
However, this mutant fails to recapitulate the level of oxaloacetate activity seen in modern apicomplexan MDHs.
The rhesus macaque model, which supports MERS-CoV replication, fails to recapitulate severe disease seen in humans.
While infection of newborn mice with hantaviruses does represent a disease model, it fails to recapitulate many of the characteristics of human hantavirus disease.
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Thus, they fail to recapitulate the full HBV life cycle.
However, most current in vivo models fail to recapitulate the biological processes seen in humans.
In this context, it is however noteworthy that FSK failed to recapitulate all the differentiating effects of DMSO.
However, our initial attempt using isogenic GLIS3−/− hESCs failed to recapitulate the defects observed in Glis3−/− mice20.
Our initial attempt using isogenic GLIS3−/− hESCs failed to recapitulate the defects observed in Glis3−/− mice20, which might be due to lack of GLIS3 expressing cells.
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