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Once the critical residues in the KTXXXI motif responsible for the interaction with Dvl1 are mutated, CXXC4 fails to interact with Dvl1 and loses its inhibitory effect on wnt signaling.
Non-interactiveness (no response to social cues; fails to interact with interviewer) 2. Facial immobility (lack of fluctuation of facial expression) 3. Postural slumping (head bowed, shoulders rolled forwards) 4. Non-reactivity (in response to attempts to cheer them up) 5. Facial apprehension (perplexity, tortured concern, etc).
Because Viacom itself does not make them available on its own sites with the same ease and thus, in Google's words, utterly fails "to interact with users, to promote [its] content to a young and growing audience, and to tap into the online advertising market".
Any entertainment brand that fails to interact with its fans is missing a huge opportunity.
Although hENT1 binds to adenosine and deoxyadenosine, it fails to interact with other nucleosides or deoxynucleosides (Fig. S3).
Furthermore, a Linker-RING finger deletion mutant parkin that fails to interact with p62 is also unable to mediate the ubiquitination of p62 (Fig. 5C).
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As in MEFs, the MUS81 loss-of-interaction mutants failed to interact with SLX4 in co-immunoprecipitation experiments (Fig. 2C).
Our results show that mutant ΔPP polypeptides fail to interact with endogenous dFMRP, suggesting that self-interactions of dFMRP and/or its interactions with endogenous dFMRP, are essential for granule formation.
In yeast, the LGMD2H mutant TRIM32 D487N failed to interact with dysbindin, whereas a robust interaction between TRIM32 P130S and dysbindin was found (Fig. 1B).
Only a construct lacking the homeo-box region failed to interact with GST-PTB1, demonstrating that the interaction with PTB1 domain of FE65 takes place within the homeo-box region (Fig. 1C).
The observed interactions are specific, as H2A nucleosomes failed to interact with these two factors.
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fails to cooperate with
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fails to register with
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fails to resonate with
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fails to mesh with
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fails to escape with
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fails to connect with
fails to convince with
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