Exact(17)
But GMM fails to efficiently handle the non-linearity and temporal dependency.
Although the higher control parameters in optimal control approach yields quicker stability, it fails to efficiently stabilize the system in the presence of perturbations.
If ICP0 accumulates, ICP4 fails to efficiently repress ICP0 mRNA synthesis (Fig. 3 6; ICP0+ treatments).
Therefore, the fact that this effect was significantly lower when similar liposomes carried B. abortus OLs demonstrates that innate immunity fails to efficiently recognize these Brucella amino lipids.
In the described experiments, we observed that, despite the presence of a polyadenylation signal, the modified LTR of HIV-1 fails to efficiently prevent read-through transcription and accumulation of ensuing fusion transcripts.
Quantitative PCR analysis revealed that treatment with inhibitors towards miR-200c, for example, fails to efficiently knockdown the microRNA, as assessed by mRNA levels of the miR-200c-targets Zeb1 and MARCKS (data not shown).
Similar(43)
It also produces increased diastolic SR Ca2 + leak with some prolonged Ca2 + sparks that at times become "metastable" and fail to efficiently terminate.
Since requirements for efficient shRNA biogenesis and target suppression are largely unknown, many predicted shRNAs fail to efficiently suppress their target.
It is notable that hamster cells fail to efficiently repair cyclobutane pyrimidine dimers in nontranscribed DNA and fail to express p48, which contains a WD motif with homology to proteins that reorganize chromatin.
We constructed a mutant virus unable to express pUL38 and found that it failed to efficiently express all viral genes tested and infected cells died of apoptosis before the viral replication cycle was completed.
To distinguish between these possibilities, we monitored GLIS3 mRNA in hESC-derived pancreatic progenitors and INS+ cells and found that the expression GLIS3 mRNA is undetectable, suggesting that the previous protocol23 failed to efficiently generate the disease-relevant cells20.
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