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Inhibition of MDM2 activity by overexpression of p14arf also fails to restore pRB stability to Lmna−/− cells, and fails to confer cell cycle arrest.
We performed a genetic cross between R6/2 mice and Hdac7+/− heterozygotes and found that genetic knock-down of Hdac7 fails to confer any improvement to a number of physiological, behavioral and transcriptional phenotypes.
Interestingly, though HKLM vaccination fails to confer protective immunity, irradiated Listeria monocytogenes (IRLM) immunization was successful in protecting mice from secondary infection [ 71].
Our analysis confirms that completing secondary education has a protective effect on IPV risk, whereas primary education alone fails to confer similar benefits [ 27].
Without recruitment of Sp1, p53 fails to confer pro-apoptotic transcriptional repression and, although pro-apoptotic genes are induced, efficient apoptosis is not triggered.
Although anesthetics had been used to induce hypothermia, sevoflurane post-conditioning fails to confer additional anti-inflammatory effects after cardiac arrest.
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This is exemplified by the results of the recent STEP trial, which showed that a HIV-1 vaccine that conferred protection in non-human primates not only failed to confer protection in humans, but may have paradoxically increased risk of transmission [3], [4], [5], [6].
Arsenic-adaptation failed to confer cross-protection to mercury and cadmium stress.
See id. at 172 14-25, 173:1-2.He also failed to confer with his peers in the field of computer science.
Since traditional treatments failed to confer a survival benefit, patients were preferentially entered into clinical trials of investigational agents.
The inspector also said that "the nurse failed to confer and clarify with the physician" the amount and timing of the potassium replacement.
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