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In vitro TNF-α fails to augment drug uptake in tumour cells or to increase cytotoxicity of the drug.
Consequently, IκBζ-D fails to augment NF-κB activity in contrast to the full length protein [ 65].
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The observation that the knockdown of PERK failed to augment the secretion of Env proteins in vitro may explain the lack of augmentation of the primary CD4+ T-cell response, which is largely driven by the uptake and processing of extracellular antigens by dendritic cells, a class of professional antigen presenting cells (APC) [60], [61].
A1 ATTACK ON KABUL -- Afghanistan's capital passed a quieter night as Northern Alliance forces fail to augment American bombing.
Contrary to our predictions, RES surprisingly exacerbated the effects of PPX on disadvantageous decision-making, even though it failed to augment PPX-induced decreases in phasic dopamine release.
However, in the case of TPC-1 cells the anti-ALCAM antibody I/F8 failed to augment cell motility.
On the contrary, irrespective of its comparable levels, NKG2D-mediated co-stimulation failed to augment IFN-γ and TNF-α production in CD28Hi naïve/memory T cells.
Exposure to hypoxia in p53 null cells failed to augment caspase-3 and -7 activation, DNA fragmentation and apoptosis.
By contrast, a cell-cycle-arrest-dead Vpr mutant failed to augment 14-3-3 14-3-3 14-3-3 with Cdk1 and CyclinB1.
However, similar overexpression of WNT5A in Rab8a −/− MEFs failed to augment Wnt reporter activity (Fig. 2B), suggesting that Rab8a −/− MEFs might not properly secrete the transfected WNT5A.
Pre-treatment of neutrophils with a combination of IDs prior to TNF-α stimulation failed to augment the effects of TNF-α on neutrophil adhesion to HUVECs.
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