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U fails to associate environmental change with natural selection.
Replacement of the Noc4p-Noc-domain by its homologues Noc1p-counterpart results in a hybrid Noc4p variant which fails to associate with Nop14p and pre-ribosomes.
In addition, while both kinases Grk3 and Grk6 bind to WT CXCR4 and are critical to its trafficking to the lysosomes, Grk6 fails to associate with the WHIM-mutant receptor whereas Grk3 associates normally.
If Gap1 is assembled under conditions preventing ER-associated SL biogenesis, the protein exits the ER normally and reaches the plasma membrane, but is improperly folded and inactive, fails to associate with SL- and sterol-rich membrane fractions, and is subject to rapid down-regulation [5].
Without lncRNA binding, WDR5 fails to associate effectively with chromatin and is rapidly degraded.
Thus, non-ubiquitinated BECN1 fails to associate with PIK3C3 and activate its kinase activity, leading to autophagy suppression.
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In a separate experiment, the group found that knockout mice missing an enzyme that normally degrades the PNN performed badly on a basic fear-association task: The animals failed to associate a shock with a beep.
Even the most naïve viewer could not fail to associate the Crusaders with the Israelis and Americans or Sa'war — the corrupt Egyptian leader — with President Hosni Mubarak.
WHAT YOU'LL FIND Many people fail to associate housing with the Hub because of its reputation as a crossroads of commerce: Third Avenue has even been called the Broadway of the Bronx.
However, locals often failed to associate the fact that, apart from the water looking dirty or clean, livestock wastes often increase the chances of nitrate pollution.
Finally, in Experiment 3, snails failed to associate an odour with the presentation of food in the presence of other odours that already reliably predicted its presentation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com