In addition to obtaining adherence estimates, participants provided data on reasons for failing to adhere to medication regimens, such as forgetting, not having their medicines with them while traveling, worries regarding side effects, and stigma/confidentiality concerns.
In the failing group estimated adherence ranged from the 58% to 99%.
Improper treatment of drug-resistant TB, such as using too few drugs, relying on poor quality second-line drugs, and failing to ensure adherence to treatment, will likely lead to increases in XDR-TB.
The reasons for failing to document adherence problems should also be explored, as should the reasons why doctors use implicit or short statements within the medical record, and whether use of explicit or implicit statements is related to the probability that the admission was MRH-related.
Despite a range of benefits, non-adherence to statin medication is prevalent with 50%to75%5% of patients failing to adhere to treatment within the first 2-years.
Indeed, other studies reported that adherence to 5-ASA therapy is low, as many as 60% of patients failing to adhere to a prescribed dose regimen and taking <70% of their prescribed medication [ 23, 24].
If adherence involves taking medication as prescribed, and non-adherence involves failing to take any prescribed medicines, all other patterns can be considered partial adherence or partial non-adherence.
Though virologic testing would likely hasten the switch to second-line among those failing, methods to improve adherence is critical to maximize durability of ART and improve virologic outcomes among youth in resource-limited settings.
Adverse events are poorly defined, with 6 studies failing to exceed 50% adherence to the items in the checklist.
Measures of plasma drug concentrations confirmed the poor adherence in failing patients; NVP plasma concentrations were inadequate (<3000 ng/ml) in 14 out of 22 (63.6%) patients and LPV plasma level was below the limit of quantification in 10 out of 10 failing patients.
