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Microarray data indicate that MCA5 (Tb09.211.4760) is upregulated in PCF, but qRT-PCR data failed to validate this, suggesting more equivalent expression, also in agreement with earlier work [ 66].
Subsequent studies failed to validate this finding, however, probably because most of these studies focused on primary breast tumors instead of metastatic lesions and employed techniques that had low sensitivity for detecting rare mutations in the background of the wild-type alleles.
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Webb doesn't come down on either side of the argument, but instead leaves you with the following quote from the book Thinking-based Learning by Swartz et al. "A presidential commission concluded that various U.S. intelligence agencies failed to validate the reliability of their sources in assessing pre-war conditions and events in Iraq.
Despite a careful replication study design, we failed to validate the initial findings for any of these variants, with the possible exception of MAPT, SORL1 and TFCP2 for which some nominal but inconsistent evidence of association was observed.
Our evaluation shows that 10-year increment bias is substantial, almost 17% on average, and our tests failed to validate the model for every one of the 30 most common tree species in the region.
However, the results failed to validate the EKC hypothesis and also ignored the cause and effect connection.
While meta-analyses of studies examining medical expulsion therapy (MET) appear to support alpha-blockers, a high-quality randomized controlled trial, enrolling patients from one geographic region, failed to validate the benefits of MET in that study population [6].
"Secure Transport failed to validate the authenticity of the connection," Apple writes on its support site.
But a statement on its support website was blunt: The software "failed to validate the authenticity of the connection".. Apple released software patches and an update for the current version of iOS for iPhone 4 and later, 5th-generation iPod touches, and iPad 2 and later.
Several studies have failed to validate the initial GWA finding of the INSIG2 rs7566605 C-allele contributing to the pathogenesis of obesity.
We failed to validate the mutations in LRP5 and MUC6.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com