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While the lowest dose failed to reduce the effect of IS (p ≥ 0.46), JNJ-17203212 at a concentration of 3 mg/kg significantly attenuated the IS-induced c-fos expression at the levels C1 and C2 of the TNC (14.8 ± 2.9, p = 0.038 at C1 and 11.2 ± 2, p < 0.001 at C2).
As expected, z-VAD-fmk inhibited by 30 40% Imatinib-mediated loss of cell metabolism in K562 cells at 48 h [22], whereas it failed to reduce the effect of acadesine (Figure 1C).
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Despite several efforts in introducing screening programs, poor countries fail to reduce the effects of cervical cancer due to innumerous problems related to cultural aspects, lack of human resources and infrastructure, lack of political commitment and limited economic investments [ 2].
According to predictions, oFbxl3sv and oFbxl21sv proteins failed to reduce the repressive effects of oCRY1, likely due to the truncated F-box motif and lack of the CBD, respectively.
In large prospective controlled studies, prophylactic volume expansion therapy failed to reduce the incidence of clinical or TCD-defined vasospasm, did not improve CBF, and had no effect on outcome [ 77- 79].
Conclusions: Pretreatment with nimesulide failed to reduce the fraction of cells that responded to prostaglandin F2α.
The addition of aminoglycoside to Cefazolin failed to reduce the rate of SWI.
However, such approach not only reduced the cost-effect benefit of nextgen sequencing technologies, but also failed to reduce the systematic bias of the sequencing platform.
Forty years of strenuous efforts have failed to reduce the production and consumption of illicit drugs.
Hence, therapeutic interventions to reduce the effects of such stress may have beneficial effects.
The results also showed that insertion of the BGHpolyA signal failed to reduce or eliminate this position effect, irrespective of promoter type (Fig. 6, vectors E and F).
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