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These cells, however, failed to recapitulate the early stage of trophoblast development.
First, introducing or increasing levels of NR5A receptors failed to recapitulate an ATR response in non-responsive cell lines.
There were also examples in which psoriasiform phenotypes failed to recapitulate a robust gene expression indicator of human psoriasis.
However, in all these transfer experiments, the CNS lesions induced by NMO-IgG were distinct from lesions found in human Devic's patients and in particular, failed to recapitulate a vast extent of demyelination [17].
However, the current mouse models do not exhibit overt neuronal loss and have failed to recapitulate the progressive degeneration of nigrostriatal dopaminergic neurons; the hallmark pathology underlying the clinical motor symptoms of PD.
This presents a conundrum, as our mutation trials in the modern enzymes failed to recapitulate the historical swap in specificity.
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However, most current in vivo models fail to recapitulate the biological processes seen in humans.
However, current macroscale methodologies to produce these niche models fail to recapitulate the spatial and temporal characteristics of the complex native stem cell regulatory systems.
Conventional dental composites with randomly dispersed inorganic particles within a polymer matrix fail to recapitulate the aligned and anisotropic structure of the dentin and enamel.
Although animal models, such as transgenic mice, provides crucial clues of many diseases, many of them fail to recapitulate the human disease condition precisely.
Monolayer cultures fail to recapitulate the native microenvironment and therefore are poor candidates for pre-clinical drug studies and studying pathways in cancer.
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