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A previous systematic review of trials examining the diagnostic accuracy of CRP in radiologically confirmed pneumonia failed to demonstrate sufficient sensitivity or specificity to be clinically useful; however, the reviewers acknowledged that the methodologic quality of the included studies was too weak to draw definitive conclusions.
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The new report says the Bush administration has failed to demonstrate sufficient urgency, focus or follow-through.
Only one item, the capacity to self-administer medications failed to demonstrate sufficient agreement (69%, 0.38).
Finding 66 people suitable for randomization entailed screening 440 residents, most of whom failed to demonstrate sufficient behavioural disturbance.
Both attempts described adequate activation of CAR T cells, but Wilkie et al. [ 115] failed to demonstrate sufficient cytokine release.
Model building in this limited subset led to models with significant effects from a statistical perspective, but which failed to demonstrate sufficient predictive power to be useful.
Despite a strong preclinical rationale and promising preclinical and early phase data, BI 2536 has failed to demonstrate sufficient efficacy in phase II clinical trials to date and development has been discontinued.
Whilst treating infections remains paramount, opportunistic approaches have largely failed to demonstrate sufficient coverage among the target population [ 8], have tended not to achieve sustained screening engagement over time or show effectiveness in reducing population prevalence [ 9].
While in this sample the improvement of depressive patients treated with olanzapine monotherapy was satisfactory [ 7], olanzapine monotherapy failed to demonstrate sufficient efficacy in a specifically designed clinical trial [ 11].
Although these results were replicated in Fmr1 mutant mice (Dolen et al., 2007; Yan et al., 2005), clinical trials for mGluR antagonists failed to demonstrate sufficient efficacy for some behavioural parameters in human fragile X patients (Jacquemont et al., 2011).
Newmark said Walker had "consistently failed to demonstrate any sensitivity to the impact of her words and actions upon the Jewish community.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com