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This study predates by a decade a much larger randomised study which also failed to demonstrate a difference between the efficacy of high-dose interferon-β and that of glatiramer acetate.
It is therefore possible that we failed to demonstrate a difference between the colistin and tobramycin groups because of our limited sample size.
Finally, a 3-month three-way crossover double-blind RCT compared the efficacy of another ginger extract with ibuprofen and placebo in knee and hip OA but failed to demonstrate a difference between placebo and ginger extract as assessed by VAS of pain and LFI [ 115].
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Indeed, other previous studies on healthy subjects at similar baseline settings also failed to demonstrate a difference in PTPdi between FM and HS[ 11], and between HS and SB [ 21].
However, two previous studies failed to demonstrate a difference in clinical outcomes between isolated TP and pleuro-pulmonary TB [ 6, 10].
Furthermore, Western blot analysis failed to demonstrate a difference in Akt gene expression between parent and resistant subpopulations.
We confirmed a difference in the intensity of immunoreactivity of GDF15 between normal mucosa and invasive tumour tissue, but failed to demonstrate a difference in the fraction of GDF15-positive cells between normal tissue and invasive tumour tissue.
Analysis of Danish data has failed to demonstrate a difference in key outcomes, such as preterm birth between medical and surgical abortion, but this study was unable to identify spontaneous versus induced preterm birth.
Similarly, the recent SPLIT trial also failed to demonstrate a significant difference between saline and a balanced solution (Plasma-Lyte) in critically ill patients [26], although this study has been subject to a lot of criticisms [21].
Despite this a group comparison investigating the frequency of responders failed to demonstrate a significant difference between the functional motor control group and the strengthening group.
The MUC1 expression also failed to demonstrate a significant difference between unifocal and multicentric/multifocal disease in both the MG (p = 0.840) and the TC group (p = 0.183).
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