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In contrast, isometheptene racemate failed to constrict the porcine MMA [9], but the fact that it produces severe arterial vasospasm [10, 11] supports its vasoactive action on dilated cranial and cerebral arterioles [12, 13].
Our results showed that, in the absence of extracellular Ca2+, U46619 failed to constrict the isolated small mesenteric artery segments.
These anucleate-cell rings were qualitatively less intense compared to those in the nucleate cells and failed to constrict.
The other half reproducibly failed to constrict the retinal arteries, and some showed paradoxical vasodilation (54).
Similar to phenotypes seen previously when imp2 is deleted (Demeter and Sazer, 1998), imp2 C) cells often failed to constrict their CRs, disassemble CR remnants, and separate daughter cells.
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Such patients suffer a severe drop in blood pressure when they stand because blood pools in their legs when vessels fail to constrict.
Signs of increased ICP include decreasing level of consciousness, paralysis or weakness on one side of the body, and a blown pupil, one that fails to constrict in response to light or is slow to do so.
We note that daughter buds are still formed yet fail to constrict.
Interestingly, the parasites then can undergo additional rounds of budding, but again fail to constrict their basal complex.
Brain herniation is shown by a lowered level of consciousness with a Glasgow Coma Scale (GCS) score of 3 8, plus one or both pupils may be dilated and fail to constrict in response to light [ 8], which is confirmed by a head CT scan.
1) Loss of OCRL causes a defect in CCP maturation at the level of u-shaped CCPs that apparently fail to constrict, yet the numbers of CCVs seen in electron micrographs is normal, a finding that seems inconsistent with the accumulation of clathrin-coated endocytic vesicles propelled by actin comets in OCRL mutant cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com