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Apart from these findings, our study shows that Smac-mimetics as a single agent induce neither cell death nor NF-κB activation in androgen-independent prostate cancer cells, suggesting that both apoptosis and NF-κB failed to be activated by the Smac-mimetic alone in chemo- or radioresistant cells with constitutively active NF-κB signaling.
OnOr4/2 failed to be activated by any of the components tested, with the exception of a very slight response to the antagonist Z9 14 OAc (Figure 2C).
Only the EPB41 gene failed to be activated following beta-estradiol stimulation.
To more directly study the role of 670.20 in galactose metabolism, we measured the gene-expression response of 670.20 mutants to a shift from raffinose to galactose and observed a set of genes that failed to be activated by galactose in the 670.20 mutant.
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These chimeras bind insulin but fail to be activated being retained at the cell surface.
This chimera binds insulin but fails to be activated or internalized.
In chicken [ 19, 20] expression of TLR1La or b, or TLR2a or b alone fail to be activated by exogenous agonists; however heterodimers of all four TLR1/TLR2 combinations were activated by both diacyl (Malp-2) and triacyl (Pam3) lipopeptides, with the exception of TLR2a/TLR1Lb, which was activated by Pam3 but not Malp-2.
Interestingly, wtCBS labeled with NAI failed to be fully activated upon AdoMet binding while modification of wtCBS by NHS, which exhibited similar modification pattern as NAI (Table 2), did not cause such effects.
Hence, when the main module fails, the spare module's activation takes a certain amount of time to be activated.
Consequently, it will be possible to discern if specific T cell lineages fail to be fully activated in patients with HPV-associated cervical lesions.
After discussing with experts in the field, our initial assumption is that if the initial load of pathogen is low, AIR progression has a chance to end with a Persistent Infection because immune responses fail to be fully activated at the beginning of infection.
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