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Our recent data supported this claim as TDSCs (CI) showed altered fate, with higher chondro-osteogenic differentiation potential but lower tendon-related marker expression compared to TDSCs (HT), which might contribute to pathological chondro-ossification and failed tendon healing in this animal model [ 18].
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6 of the 8 subscapularis tendons failed at the tendon mid-substance; the other 2 failed at the bony insertion.
6 of the 8 specimens failed at the tendon mid-substance; 2 specimens failed at the bone-tendon insertion.
It has been known that several factors, including advanced patient age, large tear size, severe muscle atrophy and fatty infiltration, systemic metabolic diseases and smoking are associated with failed or poor tendon healing (Montgomery et al. 2012).
Those that failed at the tendon were not included in the data analyses.
These deleterious changes of the muscular architecture are not reversible with current repair techniques and are the main factors for failed rotator cuff tendon repair.
Some studies indicate that cadaver tendons used to reconstruct the knees of young, active athletes are up to four times more likely to fail than tendons grafted from their own bodies, said Trojian.
Linear traction continued until the suture materials were ruptured or tendons failed, and the breaking force was recorded immediately before failure.
No difference in load to failure was found between the 2 groups at 16 weeks postoperatively, although control repairs more frequently failed at the tendon-to-bone interface (45.5% vs. 22.7%; P = .111).111
Scx-null mutant mice tendons displayed poor organization in anchoring tendons whereas the force-transmitting tendons drastically failed or were even completely absent11,12.
The manner in which the patella/allograft unit failed (bone bridge or tendon) was documented through digital photographs.
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