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But those things are going to fail relatively frequently.
At present, most of the drug candidates fail relatively late during the process (phase III) of clinical trials due to lack of efficacy [ 20, 21].
The results in terms of number of failures is slightly worse than expected, though most of those are tiddlers who failed by relatively small amounts.
The surface roughness of the adaptive coating materials played a significant role in their performance within multilayered coatings, where rough coatings (> 100 nm Ra) failed after relatively few sliding cycles.
As shown in Supplementary Figure S2, although OptGene and GDLS successfully identified knockout sets when using a small number of reaction knockouts, they failed when relatively large numbers of simultaneous knockouts were necessary for the metabolite productions.
"I've seen transactions more advanced than this fail, a relatively small percentage, but it can happen.
The most important contribution of our study is our finding that amyloid fibrils fail at relatively small strains of 2.5%4%%, and at stress levels in the range of 1.02 to 0.64 GPa, in good agreement with experimental findings.
Many compounds that would fail the (relatively recently introduced) ICH-S7B and E14 guidelines have reached the market before and are not associated with TdP.
It is an extraordinary journey and one that owes much to Allardyce who has succeeded where many of his Premiership counterparts have failed despite the relatively meagre resources at his disposal.
All beams failed in a relatively brittle manner due to the fiber rupture.
Failure analysis was applied to a hydraulic actuator piston made of aluminium alloy 7075 T6 which failed at a relatively low number of cycles.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com