Sentence examples for failed pharmaceuticals from inspiring English sources
The present study analyzes 976 chemicals (including failed pharmaceuticals, alternative plasticizers, food additives, and pesticides) in Phases I and II of the U.S. EPA's ToxCast project across 331 cell-free enzymatic and ligand-binding high-throughput screening (HTS) assays.
ToxCast aims to understand the potential health risks of a large number of diverse chemicals including failed pharmaceuticals, commodity chemicals, and pesticides by employing a large array of high-throughput screening methodologies.
These failed pharmaceuticals were provided to the U.S. EPA by Pfizer (New York, NY), Merck (Summit, NJ), GlaxoSmithKline (Research Triangle Park, NC), Sanofi (Bridgewater, NJ), Roche (Indianapolis, IN), and Astella (Northbrook, IL), with the understanding that the identity, structure, and toxicity data would be made public.
In ToxCast phase II, another 767 compounds, including some failed pharmaceuticals, were screened using around 700 HTS assays.
4 generic products failed pharmaceutical equivalence due to significant differences in potency; however, all products were undistinguishable from the innovator in terms of MIC and MBC.
In part because so many drugs fail, large pharmaceutical companies that are working on dozens of drug projects at once spend $5 billion per new medicine.
The concept of multispecific antibodies is of high therapeutic interest but has failed to produce pharmaceutical products due to the poor biophysical properties of such molecules.
And the idea of spending millions of dollars to develop a treatment for an injury that affects only 2,000 or 3,000 people every year failed to entice pharmaceutical companies.
The F.D.A. will review the experimental drug, known as CCI-779, as a treatment for renal-cell carcinoma after initial therapy has failed, said American Home's pharmaceuticals unit, Wyeth-Ayerst Laboratories.
Other agents mentioned in the documents as potentially useful, he said, are convulsants, or drugs that induce cramps, and pharmaceuticals that failed development trials because of harmful side effects.
The library contains the compounds in the U.S. EPA's ToxCast™ Phases I and II, including approximately 150 pharmaceuticals that failed in clinical trials (U.S. EPA 2013f).
