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The disease status is given in Table 2. Three (19%) patients have failed locally, one with persistent disease and two with a local recurrence at 9 and 14 months.
Two of the patients who failed locally presented with locally advanced T3 tumours.
This was either because the server running the program failed locally such as the STRING searches or no convincing results were obtained.
Eight patients have relapsed with distant metastases (of whom seven presented initially with T3/T4 disease) – of these, five have also failed locally.
This described a prolonged survival in resectable pancreatic cancer patients who remained free of local recurrence for more than two years after surgery and IORT (5-years OS 28%) compared to those who failed locally (5-year OS 0%).
Similar(55)
For example, in locally advanced lung cancer and non-HPV head and neck cancer, patients who receive radiotherapy fail locally frequently (>50%), likely due to radioresistance, which is determinative in part of treatment success.
However, the frame fails locally in the other fire scenarios.
It is evident that the frame fails locally in case of fire alone and the IO level of performance.
Despite the routine use of adjuvant chemoradiation for curatively resected stage II and III rectal cancer a significant percentage of patients ultimately fail locally and/or distally; this underscores the need for continued improvement in the efficacy of combined-modality therapy and quality of rectal cancer resection.
Patients who fail locally only will not be considered as having an event and their time will be measured from randomisation to their last known follow-up date.
In contrast to other forms of mucosal melanoma, lesions of the head and neck have the tendency to fail locally before systemic spread, and a radical resection is often difficult to achieve in these regions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com