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It is not clear why we failed to observe enhancement of signaling or growth in tumors by the antibodies, and it is possible in the MMTV-Wnt1 model that Wnt signaling levels are already maximal.
The genetically altered, hyper-adrenergic heart ultimately failed after initial enhancement of cardiac function.
A recent efficacy trial in South African infants failed to demonstrate enhancement of protection over BCG alone.
However, this degree of enhancement failed to increase the cytotoxicity of the rGel, suggesting that the rGel could not escape from the compartment into which CPE delivered it.
In contrast, our assays failed to prove enhancement of ROS on 4HPR-treated normal and activated peripheral lymphocytes (data not shown).
The questions of optimal scheduling have been addressed in limited studies combining radiotherapy with a number of anti-angiogenic agents (Williams et al, 2004; Dings et al, 2007; Shibuya et al, 2007) A study using concomitant PTK787/ZK222584 failed to show enhancement over radiotherapy alone, and study results showed that drug therapy after irradiation was optimal (Zips et al, 2005).
Another feature of this device that needs some improvement is the reproducibility of enhancement: out of the 20 devices that were tested, 2 failed to enhance fully.
The Landsat ETM+ bands of 2013 were corrected for the SLC-off (Scan Line Corrector failed) by using image enhancement techniques and nearest-neighbor interpolation.
Furthermore, MDA-MB 231 cells transfected with a siRNA targeting HIF-1α failed to show significant enhancement of exosome release after hypoxic exposure (1.12-fold; P = 0.39) compared to cells transfected with a negative control siRNA (1.45-fold; P = 0.027).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com