For samples that failed classification by the ANN, the spectra should be reanalyzed using the spectral database since all spectra that failed identification by ANN were identified correctly by the FTIR spectral database.
By analysis of candidate novel miRNAs, we found some of them can be classified into the conserved miRNA families, for example, the seed sequence of miR-new42 is exactly the same as the miR-28 and miR-708's.The 5' end sequences are crucial for classifying the miRNA families, and a change in even one base pair can result in failed classification of members of the same family.
As identification results three different classifications are possible: (i) correct identification, (ii) incorrect identification, or (iii) failed (unknown classification).
Table 4 shows P scores for each sequence and indicates which passed or failed at classification.
Gallagher was selected to compete at the 2008 Beijing Paralympics in long jumping, 100 m, shot put and discus, but she failed her classification test because the classifiers said the eyesight in her right eye was 0.01% too good.
In a comparative study of the PVN classification and the modified NPI classification, although the PVN classification failed to significantly increase the HRs of tumour recurrence in the high risk-group, it significantly increased the HRs of tumour death in the high and very high-risk groups.
Due to the multimodally nature of the patches involved in our problem (i.e., colours, orientation, shape, etc)., a single discriminative classifier could fail during classification task.
However, this study clearly demonstrated that in IDCs negative for both ER and PR, the stage IIIC of the pTNM classification failed to maintain its predictive prognostic power, when compared with the PVN classification.
On the other hand, only the pTNM classification significantly increased the HRs of tumour recurrence and death for the stage IIIC cases when compared with the PVN classification, and the NPI and HG classifications failed to increase the HRs of tumour recurrence or death when compared with the PVN classification.
Although the integrative cluster centroids did not outperform the existing luminal-A/B classification as a prognostic model, they did exhibit stronger consistency across studies as the luminal-A/B classification failed to predict prognosis in the smaller Fleischer set (Table 3, Additional file 1: Figure S6).
In other words, even when the classification failed, the predicted target direction was close to the actual direction.
