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Analysis of the μCT data allowed quantification of the physical distortion within the individual cell layers of both an untested and failed cell.
Moreover, Au NP targeting of cancer cell nuclei has been found to influence cellular function, causing cytokinesis arrest, DNA damage, and programmed cell death, which leads to failed cell division, thereby resulting in apoptosis [20].
In all cases of failed cell separation, C. albicans hyphae were observed spanning both daughter cells.
Interestingly, failed cell division following phagocytosis of hyphal C. albicans is surprisingly common, and leads to the formation of large multinuclear macrophages.
Interestingly, we observed failed cell division most frequently in clusters of macrophages exposed to and infected with multiple C. albicans hyphae.
The observation that C. albicans hyphae spanned both daughter cells in all cases of failed cell separation implies mechanical rather than active inhibition of cytokinesis.
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I e-mailed this sister for help with the Ravioli issue — how concerned should we be? — and she sent me back an e-mail, along with an attachment, and, after several failed cell-phone connections, we at last spoke on a land line.
When coordination between key cellular processes fails, cell death can result.
If this process fails, cell growth within the tissue ceases and degenerates through an avascular necrotic process.
If the adaptive response fails, cells are directed to undergo apoptosis (programmed cell death).
Whereas spacecraft have many redundant systems that can kick in, such as when a thruster fails, cells have their own backup systems for regulating gene activity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com