There are countless examples of "Google fail" (available, yes, through Google) that are constant reminders of how the service cannot account for all the intricacies and subtleties of the human experience.
These findings were particularly significant because all patients had failed previously available treatment methods.
Unfortunately, attempts to determine the H3R17 methylation status failed, as available R17 methylation-specific antibodies were found to cross-react with methylated C/EBPβ (data not shown).
If these treatment options have failed, other available therapies are suggested: midodrine (level 1 evidence), blood volume controlled ultrafiltration, use of a dialysate calcium of 1.5 mmol/l, prolongation of dialysis time or increase in dialysis frequency (level 2 evidences), L-carnitine supplementation, and/or bicarbonate dialysis (level 3 evidences) [ 55].
The genotypes of patients who had previously failed commercially available PIs were examined for the presence of DRV resistance-associated mutations and 3 or more were found in 6.7% of case but two-thirds of patients did not have any mutations detected.
But should such precautions fail, the available choices take different directions along gender lines.
LDL apheresis is an option for individuals who fail currently available oral prescription therapies.
Despite the major recent progress in the treatment of CD, some patients fail all available therapies, including immunosuppressants and biological therapies.
The prevalence of patients with gastrointestinal stromal tumourgst (GIST) who fail currently available treatments imatinib and sunitinib (third-line treatment-eligible GIST) is unknown, but is expected to be below an ultra-orphan disease threshold of 2/100,000 population used in England and Wales.
It is proposed that guidance of sepsis therapy by biomarkers may easily fail because available scoring systems (APACHE II, in particular) manage to recognize either low-risk patients or very-high-risk patients but not the patients in between these two extremes [ 26].
