Sentence examples for fail to sensitize from inspiring English sources

When the temples in our life provide nothing but excuses for that which we already want to do, and when they fail to sensitize us to those beyond the temple's walls, as was apparently the case in ancient Israel, the collapse of those temples is a reasonable, if tragic, result.

Similarly, our studies indicated that known chemotherapeutic agents such as doxorubicin, docetaxel, and 5-FU fail to sensitize ALDH + cells; however, significant growth arrest was observed in ALDH− cells in response to these agents.

As a result, rotenone failed to sensitize human PBMC to TRAIL-induced apoptosis, indicating that the sensitizing effect of rotenone is tumor cell specific.

Over-expression of catalytically inactive mutants failed to sensitize cells to FasL under our experimental conditions (Fig. 5C).

First of all, this study demonstrates that hNGFR100 fails to sensitize and activate nociception, while it shows a full neurotrophic pro-survival competence, providing a direct mechanism for pain insensitivity in HSAN V and explaining the major neurodevelopmental effects in HSAN V. We provide a mechanism for this differential neurotrophic versus nociceptive activity of hNGFR100 mutants.

The results presented here show that TAT-BID sensitizes PC3, A549 and to very low extent HeLa cells to apoptosis induced by TRAIL, but it fails to sensitize LNCaP cells.

Notably, ablation of one allele of Chk1 also failed to sensitize primary lymphocytes to IR (Supplementary Figure S1e), suggesting that mouse cells can deal better than human cells with DNA damage in the presence of reduced Chk1 activity.

Also, in these cells, PS-1145 treatment failed to sensitize the cells to TNF killing, while the alternative inhibitor IKK-VII was highly toxic at the concentration used (Supplementary Figure 2B).

In the presence of SCF, mTORC1 inhibition by RAD-001 restored in part the apoptotic response to nilotinib in CD34+/CD38+ cells (P=0.0009), whereas it failed to sensitize the CD34+/CD38−cells.

This data is in line with a previous report by Jiang et al. which showed that exogenous maspin failed to sensitize human breast tumors to chemical induced apoptosis [ 11].

Furthermore, Chk1 inhibition largely failed to sensitize normal and malignant cells from p53 −/− mice toward DNA damaging agents, and p53 status did not affect the death-inducing activity of DNA damage after Chk1 inhibition in human cancer cells.