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In Talpid3 mutant mouse embryos, centrosomes fail to dock at the plasma membrane and cilia are absent in various tissues (Yin et al., 2009), associated with embryonic lethality.
In fltp mutant MCCs, BBs fail to dock, and in mutant cochlea, BB/kinocilia are mispositioned and stereocilia bundles are misoriented and distorted.
Altogether, these results suggest that a (fraction of the) Cx26C169Y hemichannels are correctly targeted to the plasma membrane, but fail to dock to each other in neighboring cells, thus preventing the formation of gap junction channels.
For example, when one or more key residues in the AtPSKR1 GC domain is replaced with leucine, GTP is more likely to fail to dock or dock in the wrong orientation, implying compromised or abolished GC activity.
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MOSCOW — A Russian cargo spaceship experimenting with a new type of autopilot failed to dock with the International Space Station on Tuesday, in the latest glitch for the Russian space program.
If, for instance, Apollo astronauts failed to dock their command module with the lander, then the mission would be off.
About 500 passengers on a ferry from Ireland to France spent the night anchored off Cherbourg in north-west France after the vessel failed to dock.
In July 1976, Russian cosmonaut Vasily Zholobov suffered a nervous breakdown when his spaceship failed to dock at the Salyut 5 station and lost power for 90 minutes.
These cosmonauts were chosen because of their training for a similar emergency mission to the International Space Station the previous year, which would have been launched if the Zvezda module had failed to dock.
ATP failed to dock close to the P-loop which is not surprising in light of our binding studies which suggest that ATP does not bind to the enzyme in the absence of DCoA.
They were found to have migrated toward the surface; however, they failed to dock with the plasma membrane (Fig. 3DII).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com