Sentence examples for fail to align from inspiring English sources
Especially in scenarios where some of the input genomes have undergone whole-genome duplication, the positional homology alignment method may fail to align many target regions.
A noteworthy aside is that default alignment parameters often fail to align fungal repeats correctly due to complex internal repeat structures.
Exogenous expression of TRPV1 induces alignment of NIH3T3 fibroblasts that fail to align in the absence of TRPV1, further implicating TRPV1 channels as critical mediators of cellular responses to biophysical cues.
1) Unable to annotate many reads - Methods that rely on alignment of reads/contigs to known genomes still fail to align a large number of reads if they are from unknown species.
Similarly, the most divergent environmental sequences can hardly be included in comparative phylogenetic analyses, because divergent environmental sequences and sequences from cultured organisms often fail to align sufficiently well when introduced together in multiple sequence alignments.
The reference sequence for each genome must be considerably closer to that genome than to any of the others, but it is not necessary for the references to separate the sequences perfectly as the assembly graph can be used to identify spurious alignments, as well as to reallocate contigs that fail to align to any of the references.
Automated alignments have failed to align the region N-terminal to the equivalent of Ser806 critical for ATP binding.
The decrease in the sensitivities of all methods can be explained by the fact that the alignment tool fails to align increasingly noisy RF reads.
These splice junctions are either altered by a nucleotide change, fall in a region of sequence expansion/contraction, or are not represented in the alignment because the exons failed to align.
In addition, 816 segments with sequence in both genomes failed to align with LASTZ and also failed to produce consistent alignments with different Smith Waterman alignment implementations.
In each case, ∼11% of sequences failed to align, and 15% of were suppressed due to multiple alignments.
