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In Stone's world, the ruthless leave their footprints on the world and nice guys fail first and finish last.
There is no justification for insurers to prolong patients' suffering and wait for them to "fail first" before treating their disorder seriously.
But various celebrities have agreed to take over from me when I fail – first, the comedian Frankie Boyle, then Massive Attack's frontman Rob DelNaja.
After all, the best way to coax a success out of U2 is to let it fail first (its previous album "Pop").
But the drugs, which they said would need to be developed cautiously and slowly, may be years away — if they do not fail first.
An open question is whether aging cells are defined by predictable sequences of physiological changes, or whether they proceed along divergent aging trajectories defined by whichever system begins to fail first.
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We demonstrated that if treatment options are limited for those who fail first-line therapy then the prevalence of acquired and transmitted drug resistant strains of HIV could be relatively large.
Patients who fail first-line therapy have unequivocally poorer outcomes compared with optimal responders.
Currently, there is limited information on additional treatment of patients who fail first-line platinum-based chemotherapy.
NICE have gone some way to achieving this by allowing us to prescribe irinotecan for patients who fail first-line 5FU/FA.
The approved second-line chemotherapy option for patients of PS 0 1 who either cannot tolerate or who fail first-line platinum-based treatment is docetaxel.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com