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Signaling pathways are often used to regulate transcription factors to specify the genes for active transcription.
HLH-1 is the lone MRF homolog in C. elegans and it functions together with other transcription factors to specify bodywall muscle fate and direct differentiation [5], [6].
Their interaction with other tissue-specific transcription factors and their spatiotemporal expression patterns, together with mutations in the HMG domain, allow different Sox transcription factors to specify their target selection [1], [8], [9].
Using this directed graph, we then construct a list of factors to specify the factor graph.
Meanwhile, individual INPs produce distinct types of neurons by sequentially expressing a set of distinct transcription factors to specify the identity of their progeny (Bayraktar and Doe, 2013; Wang et al., 2014).
Current views on the control of cell and organ development are anchored on the notion that phenotypes are defined by precise networks of transcriptional activity, acting in a concerted way through a specific combination of transcription factors to specify cell fate [ 1].
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In mouse, it has been suggested these factors act to specify mesoderm and/or endoderm subtypes during gastrulation [34] [35].
Owing to an excellent characterization of the transcription factors used to specify fate in embryonic mice, the best-characterized hiPSC differentiation protocol is generally accepted to be one for motor neurons (Di Giorgio et al., 2008; Dimos et al., 2008), although a highly efficient method for generating midbrain dopaminergic neurons was recently published (Chambers et al., 2009).
The result of common tests can be used to evaluate the newborn exposed to certain infectious factors, and to specify the correct therapeutic attitude, but in close relation with the clinical outcome, considering their non-specificity and potential false positive or negative results.
In addition to that, we must choose a distance threshold b for the gene pair orientation classes and a scaling factor f2 to specify the degree of differentiation between head head orientations modeled by A2 and all other orientations modeled by A1.
A second model suggests that serotonin is a permissive factor required to specify the dorsal region of the embryo containing chiral cilia that generate asymmetric fluid flow during neurulation, a much later process.
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