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Transcription factors switch genes on and off in groups.
Transcription factors switch other genes on and off, and some of them are vital for turning a fertilized egg into a complex animal body.
When controlling for other LAHL risk factors, switch to zidovudine conferred 80% lower hazards of LAHL for this subgroup (HR 0.21, 95% CI 0.07 0.64, p = .006).006
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With these transcription factors switched off, Arabidopsis's flowers develop bushy leaves similar in form to witches' brooms.Further experiments showed that Arabidopsis plants with leafy flowers are indeed, as would be expected, more attractive to leafhoppers.
Murray says there were contributory factors: switching from the show's usual studio base to an outside broadcast had led to a series of production difficulties ("you'd think it was some episode of Fawlty Towers"), which meant the usual series of meetings, checks and balances hadn't happened.
Beginning in 1995, multi-decadal factors switched to a phase that suppresses Pacific hurricane activity.
Interactions often correlate with transcriptional activation, perhaps involving scanning for partner elements [ 28]; in one case, exchanging GATA factors switches contacts and so alters gene expression [ 30].
The present study investigates the molecular basis for this transcription factor switch.
The release factor switch loop (residues 286 301 in T. thermophilus RF1) plays a crucial role in regulating the active catalytic conformation of the release factor.
During GATA factor switch, the GATA-1 expression will increase due to the reciprocal decrease of GATA-2, which leads progenitor cells to adopt an erythroid lineage.
This "GATA factor switch" suggests a model whereby GATA-2 and GATA-1 sequentially bind the same cis-elements with activating and repressive effects, respectively.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com