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Transcription factors of the basic leucine zipper (bZIP) family control important processes in all eukaryotes.
The proneural genes of the achaete-scute (ac-sc) and atonal families encode related transcription factors of the basic helix-loop-helix family that function as heterodimers together with the co-factor Daughterless/E2A/HEB/E2-2 [1].
As with CDH1, these other junctional proteins are also repressed by transcription factors of the basic helix-loop-helix and zinc finger families [ 42, 45].
An E-Box motif, which binds transcription factors of the basic helix-loop-helix/leucine zipper family, is responsible for transcriptional activity, as demonstrated using mutated promoter-reporters.
These iron deficiency responses are regulated by transcription factors of the basic helix-loop-helix family, including FIT1 in Arabidopsis thaliana [ 9- 11].
E box motifs are known to bind to transcription factors of the basic helix-loop-helix/leucine zipper (bHLH LZ) family, including Myc and USF [ 20– 23].
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CLK and CYC are transcription factors of the basic-helix-loop-helix (bHLH /PAS (Per- Arnt- Sim) superfamily that heterodimerize to stimulate the daily transcription of dper and tim, in addition to other clock and downstream genes.
SREBP-1c is a conserved transcription factor of the basic helix-loop-helix leucine zipper family that primarily regulates lipogenic enzymes and directly influences the expression of FAS, ACC and SCD1 (Ha et al. 2016).
Hypoxia stabilises a transcription factor of the basic helix-loop-helix family (HIF-1 in mammals, Sima in Drosophila).
c-Myc is a transcription factor of the basic helix-loop-helix leucine zipper (bHLH-LZ) family, which dimerizes with another bHLH-LZ protein, Max.
Mash1 is a proneural transcription factor of the basic helix-loop-helix family, which participates in the commitment of neural progenitors, promotion of cell cycle exit and neuronal migration, and in the final specification of neuronal identities in the brain [60], [61].
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