Possible determinants were tested using Cox's four-level hierarchical survival model, taking into consideration the temporal proximity of the predisposing factors to interruption of EBF.
A limitation of our study is that our examination of different levels of factors affecting medication interruption is limited by the proportion of AI with medication interruption.
Moreover, excluding patients with IDU as risk factor (490 patients), a lower proportion of interruption was also detected (15.3% vs. 37.9%, p = 0.005) and finally, taking into account patients starting EFV-containing regimen from 2007 (since STR was available in Italy, 213 patients), still a significant lower proportion of interruption was observed (17.1% vs 34.1%, p = 0.03).
Among the steps required for tumor cell growth and survival are the amplification of signals from growth factors and the interruption of signals promoting cell death or apoptosis [8], [9].
Factors at the interruption of treatment associated with a higher probability of re-entering were: interruption not due to methadone withdrawal, bad physical health, and higher methadone dose.
Three factors at the interruption of treatment were associated with a higher probability of re-entering: an interruption not due to methadone withdrawal, bad physical health, and higher methadone dose.
One of the potential confounding factors of using the immortalized BEC is interruption of the p53 signaling pathway by the SV40 large T antigen, the agent used in immortalizing these cells 37.
Both hypoglycemic episodes were classified as "asymptomatic" and were not related to established major risk factors of ICU hypoglycemia such as nutritional interruption, asynchrony of nutrition and insulin administration, delayed glucose measurement, or drug administration.
All three hypoglycemic episodes were classified as "asymptomatic" and were not related to established major risk factors of ICU hypoglycemia such as nutritional interruption, delayed glucose measurement, or drug administration.
● To estimate the duration of interruption, the probability of re-entry to treatment after a first interruption of treatment, and the factors present at the end of the first treatment period that are associated with re-entry.
