To ascertain whether the rank of each of the highest ranking putative transcription factor entity was statistically significant, 100,000 random rankings of the entities in each cluster were generated.
In order to capture the essence of equivalence, and to decide about whether some structural, functional or informational feature should be the distinctive factor among entities, we must ask the following question: During the lifetime of an entity for whom or what is it relevant to distinguish between non-identical entities?
The key factor driving the changes is the relative fitness of an agent (entity).
The rank of the highest ranking transcription factor annotated entity and the significance of its position is listed in Additional file 5.
Mendel's genes were only hypothetical entities, factors that could be inferred to exist in order to explain his results.
Some other factors including the entities of immunosuppression in non-AIDS immunocompromised patients, associated co-morbidity and severity of PJP at the diagnosis may be responsible for the need of mechanical ventilation or death of the patients.
In contrast to treating a mixture of factors as single entities leading to an endpoint, systems biology relies on experimental and computational approaches in order to provide mechanistic insights to an endpoint [ 1].
60 61 Different factors and molecular entities appear to be part of the possible aetiology for MS, with specific PUFAs and antioxidants found to be key substances related to all known pathogenic and recovery mechanisms.
The therapeutic strategies to be used depend on the prognostic factors: specific anatomoclinical entities (neuroendocrine tumours, cervical lymph node metastases from squamous cell carcinoma, axillary lymph node metastases from an adenocarcinoma in women, undifferentiated carcinoma of the mediastinum in young men) and other nonspecific situations.
Finally, we recently reported that two functional variants, ABCA1 N1800H and ABCG1 g.-376C>T, were associated with, respectively, substantial reductions in levels of HDL cholesterol or reduced ABCG1 mRNA expression levels and increased risk of ischemic heart disease and myocardial infarction (12, 13)—risk factors and disease entities closely related to diabetes.
