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Subsequent binding of β-catenin to the LEC/TCF family of transcription factors converts them from transcriptional repressors to activators.
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Transient expression of NeuroD2, one of neural bHLH transcription factors, converted mouse N1E-115 neuroblastoma cells into differentiated neurons.
Alternatively, seeding in the bone is stimulated by local factors converting the tumor cells to an osteomimetic stage (reviewed in [ 17]).
Odds ratios were calculated for other factors converted to dichotomous variables (activity level, age, location of hip pain and use of a walking aid).
For several transcription factors, the half-life data were not available, so we computed a median of the half-life values for the other transcription factors, converted it and used that value for those proteins.
A scaling factor converts the differential ionospheric delay to TECU.
The number of counts was corrected for decay and, using a volume-dependent sensitivity factor, converted to activity.
Astrocyte expression of tumor necrosis factor converting enzyme (TACE/ADAM-17) may facilitate pericyte PDGFβR signaling mechanisms [ 80].
The area was converted to volume by multiplying it times a conversion factor (converted to the actual voxel size), and the known width of the slices (1 mm).
Upon ligand binding, Notch1 undergoes a concerted action of the proteolytic enzymes ADAM (a disintegrin and metalloprotease)/TACE [TNF (tumor necrosis factor -converting enzyme]/γ-secretase that ultimately release the NICD (Notch1 intracellular domain).
The stabilized β-catenin enters the nucleus, where it interacts with TCF transcription factors and converts them from repressors to activators (Logan and Nusse, 2004; Clevers, 2006).
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