Sentence examples for factor to the pathogenesis of from inspiring English sources

This novel role for Ro52, in negatively regulating IRF7 stability, may provide a mechanism to protect the host from the overproduction of type I IFNs, a contributing factor to the pathogenesis of systemic lupus erythematosus [28].

The lack of effect in other studies may have been due in part to the fact that children were kept under close observation, so episodes of malaria or anaemia were detected and treated promptly during the course of the intervention period, and partly due to the varying importance of malaria as a contributory factor to the pathogenesis of anaemia in different epidemiological settings [13].

Ionic Ca2+ in the mitochondria ([Ca2+]m) regulates not only substrate oxidation and ATP production [4], [5], but also ROS generation [6], which has been demonstrated to be a major contributing factor to the pathogenesis of diabetic complications including diabetic nephropathy [7].

Our findings suggest that deficiency in SUCNR1 is a possible contributing factor to the pathogenesis of dry AMD and thus broaden our understanding of this clinically unmet need.

Large clinical studies indicate that hyperglycaemia is a major contributing factor to the pathogenesis of diabetic vascular complications, including nephropathy [ 1].

Although it is commonly accepted that hyperglycemia is the main contributing factor to the pathogenesis of diabetic complications, studies have implicated the brain insulin resistance or defective brain insulin signaling in neurodegenerative diseases (Bassil et al., 2014).

Age, hormones and epithelial mesenchymal interactions are all contributing factors to the pathogenesis of BPH.

The aim of the present study is to determine the contribution of intrapsychic, organic and relational factors to the pathogenesis of RE and the relationship between RE and erectile dysfunction (ED) in a sample of patients attending for the first time to an Outpatient Clinic for sexual dysfunction.

Clostridium difficile toxin B (Tcd B), as one of the primary contributing factors to the pathogenesis of C. difficile-associated diseases, has raised serious public concerns due to its virulence, spore-forming ability and persistence with major types of infectious diarrhea diseases, and been used as a potential biomarker in clinical diagnoses.

Nevertheless, the exact mechanism and relative contribution of each of these factors to the pathogenesis of TPP is still unclear.

Of these, mrp, epf, and sly were considered as the most relevant factors to the pathogenesis of S. suis by many researchers [ 15– 17].