Sentence examples for factor to orchestrate from inspiring English sources

Whereas liver X receptors and their ligands are negative regulators of macrophage inflammatory gene expression 21 and constitute a metabolic checkpoint for immune-cell proliferation 22, ROR-γ is the key transcription factor to orchestrate differentiation of pro-inflammatory T helper 17 cells 23.

Nuclear RNAs emerge as important factors to orchestrate the dynamic organization of the nucleus into functional subcompartments.

For example, basidiomycetes utilize homeodomain (HD) transcription factors to orchestrate and regulate sexual development, such as the Ustilago maydis b alleles that encode two divergently transcribed HD1 and HD2 class proteins (reviewed in [48]), or the Coprinopsis cinerea A locus that also encodes two divergently transcribed homeodomain proteins [49].

In addition, Snail family proteins collaborate with other transcription factors to orchestrate concerted regulation of EMT.

For example, NeuroD4/Math3 is a dorsal bHLH transcription factor that cooperates with the proneural bHLH transcription factor, Neurog2, to orchestrate regional gene expression profiles in the developing cortex [39].

Most often, individual transcription factors collaborate to orchestrate gene expression through combinatorial binding to regulatory regions in chromatin [ 2].

One of the factors believed to orchestrate this stress hyporesponsiveness is the marked switch in progesterone and estrogen levels that occurs following regression of the corpus luteum (luteolysis).

A coordinated regulation was found of transcription factors known to orchestrate type II fiber formation (upregulation of MyoD, Six1, Six2, Eya1, and Sox6, and downregulation of myogenin and ERRγ).

This cautionary tale also suggests that other key transcriptional regulators could likewise go undetected; suggesting that more studies will likely be required to take a fuller accounting of the multiple factor combinations that have evolved to orchestrate the diversity of gene regulatory pathways during differentiation and development of metazoans.

Genetic manipulation of key transcription factors (TFs), which act to orchestrate production of multiple regeneration-associated genes, has emerged as a promising strategy.

Separate incorporation of vascular endothelial growth factor (VEGF 121 and VEGF165, known to orchestrate vascular development, into the PEI-PEGDA gel and PEGDMA hydrogel resulted in enhanced neovascularization at the implantation sites due to bimodal, sequential release of two VEGF isoforms.