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Alternatively, the persistent chronic increase in ROS production in Klotho mice may be a factor that sustains the elevated level of actASK1-signalosome → p38 MAPK activity thereby promoting the processes of aging [ 21].
What we know about the role of Dock10 comes from a single study using gene silencing, showing Dock10 as a factor that sustains the rounded morphology and amoeboid-type movement in melanoma cells (Gadea et al., 2008).
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This makes it more difficult to predict the future carbon flux driven by coccolithophores, because the environmental factors that sustains a bloom (e.g., light; see [54]) could also be affected by the ongoing climate change.
Only 9% said they felt that such measures helped the capital markets to make an "appropriate valuation" of their company.The factors that sustain long-term corporate returns are but vaguely understood.
Additionally, Volet et al. (2009a) identify those factors that sustain group engagement in high-level co-regulation and contribute to improve the quality of regulation, such as asking questions or giving explanations.
Such a framework is also needed to elucidate factors that sustain coral health.
Together these frameworks help explore factors that sustain organizational changes.
Factors that sustain self-renewal of mouse embryonic stem cells (ESCs) are well described.
There is a danger of forgetting about the "social and political factors that sustain perceptions of health system constraints" as being unavoidable, and therefore acceptable [[ 26]: p.1384].
Inflammatory cells provide growth factors that sustain proliferation, and survival factors that allow escape from apoptosis; it also contributes to extracellular matrix (ECM) modifying enzymes, and to pro-angiogenic factors that facilitate angiogenesis, invasion and ultimately metastasis [ 3].
While there is much written about the introduction of innovation [ 10], such as new roles in health care, there is little that considers the factors that sustain innovation [ 11].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com