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NF-κB is a well-recognized transcription factor that directs the production of pro-inflammatory chemokines8.
Corynebacterium glutamicum σA is an essential primary σ factor that directs the transcription of the majority of genes expressed during exponential growth which are termed "housekeeping" or "vegetative".
σ32 (RpoH) is the sigma factor that directs the transcripts needed to respond to heat shock and other stress conditions.
NFE2L2 is a transcription factor that directs response to stress and oxidative damage in cells.
An important factor that directs the clinical course of leprosy is the presence of proinflammatory and anti-inflammatory cytokines.
They identified Olig2 as a prepatterning factor that directs the recruitment of Brg1 to OL lineage-specific cis-regulatory elements during the critical transition from OPCs to OLs.
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In addition, a plethora of investigations showed that the Pax6 protein consistently works within a similar group of proteins (called a developmental cascade or network of transcription factors) that directs eye development by regulating the expression of many different genes.
Thus it appears that Arl5 is one of the factors that directs the recruitment of the GARP complex to the trans-Golgi, and this function is conserved in both flies and humans.
EIN3 and EIN3-LIKE1 (EIL1) are the transcription factors that direct the expression of ethylene-responsive genes, and EIN3 loss-of-function mutations confer ethylene insensitivity [ 7, 31].
Another group presented further insight in signaling pathways, including Notch and hypoxia inducible factor that direct endothelial cell heterogeneity, which might have consequences for diseases affecting different parts of the vascular system.
Each of the regulators that acts upon the csf1r has been attributed functions in myeloid lineage commitment; this area has been reviewed recently.123 Alongside the genes that control what might be called the generic MPS program, there are, undoubtedly, factors that direct subsets of MPS cells to particular phenotypes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com