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Nuclear factor (NF -κB is a traNF -κBtisn factranscriptionor the development and control ofactorammation.
TWIST1, a transcription factor pivotal for metastasis by promoting epithelial-mesenchymal transition [ 61- 64], was part of the gene expression signature identified in EpCAM-enriched cells from BM of breast cancer patients after chemotherapy.
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VEGF is a potent angiogenic factor pivotal in OA pathogenesis.
We propose that two factors are pivotal for successful two-photon imaging of islet autoimmunity: induction of synchronized insulitis and genetic labeling of the transferred cell population with a strong fluorophore.
Both genetic and environmental factors are pivotal for the induction of type 1 diabetes.
"In an age when there are very few truly mass-audience platforms left, the X Factor has become pivotal for those labels and artists seeking to reach a family-based audience," says Gennaro Castaldo of HMV, one of the few music retailers that retains a high-street presence.
Consequently, the clinical incorporation of predictive and prognostic molecular biomarkers together with traditional clinical prognostic factors will be pivotal for future management of patients within this large subgroup.
TFPI-1 does not affect the internalization of factor VIIa, which is pivotal for further TF-dependent signaling [ 84], and requires factor Xa for the formation of the inhibitory quaternary complex [ 85].
Inhibition of key inflammatory factors is also likely pivotal for mediating the potent anti-inflammatory activities of adenosine and PGE2 in neutrophils.
Interestingly, three tandem repeats of a CTGGAGGC element, surrounding the transcription start site and bound by specific nuclear factors, were found to be pivotal for the promoter activity.
Sertoli cells could secret a number of growth factors and cytokines that are pivotal for spermatogenesis [ 50, 53].
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