Sentence examples for factor independence from inspiring English sources

For example, in NIH3T3 mouse fibroblasts, as well as Rat1 fibroblasts, Rac1V12 expression confers growth factor independence, whereas Cdc42V12 expression confers anchorage independent growth [ 8].

With IL-3 in the media, selection for growth factor independence was avoided.

Using a triple mutant of BCR-ABL (Y177F, ΔSH2, and ΔPro), we show that this mutant still confers growth factor independence to 32D cells (Figure 1), but exhibits a profound defect in the transformation of primary hematopoietic cells.

In contrast, the significantly reduced activity of the MAP kinase and PI3-kinase/AKT pathways suggest that they are not required for BCR-ABL to induce growth factor independence in the triple mutant cell lines.

Dicer-null NS cells do not appear to be transformed to an oncogenic phenotype, as they show a marked dependence on growth factor signalling for survival, whereas a classic hallmark of the cancer cell is its growth factor independence [46].

In addition, our previous data indicates that the CA-CSF-1R Y561F is equally competent for signaling as it can induce growth factor independence in MCF-10A cells and promote MCF-10A acini growth similar to CA-CSF-1R [8].

Growth factor independence-1 (Gfi1), B cell leukemia/lymphoma 11b (Bclysine lysine methyltransferase G9a, and ETS1 are also essential for the development of ILC2s (Spooner et al., 2013; Walker et al., 2015; Yu et al., 2015; Zook et al., 2016).

Growth factor independence-1 (Gfis) is a zinc finger transcriptional repressor that regulates hematopoietic stem cell maintenance, pre-T-cell differentiation, formation of granulocytes, inner ear hair cells, and the development of secretory cell types in the intestine.

The growth factor independence-1 (GFI1) transcription factor is essential for the development of neuroendocrine cells, sensory neurons, and blood.

Immediately upstream of the core promoter, there is a silencer element that contains a putative growth factor independence-1 (GFI-1 -binding GFI-1 -binding

The abnormal SOCS1 expression in psoriatic keratinocytes depended on an alteration of the transcriptional machinery regulating its promoter function, involving growth factor independence-1b and Kruppel-like factor 4 transcription factors.