Adding complexity to the topic of FGF as a prognostic factor in NSCLC, the implications of increased FGF expression have been shown to differ based on its presence in tumor cells (negative prognostic marker) versus stroma (favorable prognostic marker) 46, 47, with stromal expression postulated to inhibit NSCLC progression 48.
Here, we provide an overview of these factors in considering the implications of genotypic diversity for disease pathogenesis, vaccine efficacy, and drug treatment.
Understanding the relationships between these factors, and the implications of any fluctuations in their ratios, is essential in formulating a sound investment strategy.
Future functional co-culture studies may be able to tell us more about the specific effects of these dNK cell-derived factors and the implications of these effects in normal and pre-eclamptic pregnancies.
Using photographs as a factor in the admissions process could have negative implications, if history is any guide.
There is growing consensus that nanoparticle aggregation is an important factor in understanding the health implications of nanoparticles.
More importantly, even if dosage were acting as a confounding factor in this way, the implication for clinical practice remains the same: altering the treatment of a patient who is otherwise stable is associated with a rise in the risk of relapse and hence should be avoided.
Here we found that HIF-1 from TAT recruits highly on the human VEGF promoter than from SAT, suggesting the potential implication of this transcription factor in the regulation of VEGF, especially in TAT.
However, they are contraindicated in some patients due to their multiple effects on various target tissues and implication as a risk factor in the development of breast and uterine cancers.
She wrote: "The implication of your article – that the behaviour of the students was in some way a factor in the collapse – has caused deep offence".
