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As obesity is a key factor in the development of type 2 diabetes, lowering lipid accumulation in adipose tissues is as important as increasing insulin sensitivity in diabetic patients.
Insulin resistance, which is a major factor in the development of type 2 diabetes [2], is a common metabolic feature in myotonic dystrophy 1 (DM1), an autosomal dominant neuromuscular disorder [3].
Inflammation is believed to be an important factor in the development of type 2 diabetes and fatty liver disease.
Increased adipose tissue is associated closely with the development of insulin resistance and is the principal risk factor in the development of type 2 diabetes mellitus.
The central etiological factor in the development of type II diabetes mellitus (T2DM) is the resistance of fat, muscle, and liver to insulin [ 3].
Insulin resistance, considered by some as one of the key components of the metabolic syndrome, is an important factor in the development of type 2 diabetes even in individuals with normal glucose tolerance [ 10– 13].
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In addition to HLA associated genetic predisposition, the role of exogenous factors in the development of type 1 diabetes (T1D) is well admitted.
Multiple studies have demonstrated the shared contribution of both genetic and environmental factors in the development of type 2 diabetes mellitus [ 1, 2].
T2DGADB aims to provide specialized information on the genetic risk factors involved in the development of Type 2 diabetes.
Many different factors are involved in the development of type 2 diabetes.
The rise in type 2 diabetes is tightly connected with a dramatic increase in obesity, a major risk factor for the development of type 2 diabetes [ 1].
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