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It is known that free radicals are a major pathogenic factor in the development of ischemic damage in the muscle tissue [8].
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Candidate gene association studies, linkage studies and genome-wide association studies have highlighted the role of genetic factors in the development of ischemic stroke.
In addition to studying the role of above-mentioned cardiovascular risk factors in the development of ischemic small vessel disease, we also directly investigated associations of atherosclerosis with these markers.
Metabolic syndrome is linked to chronic inflammation - another major risk factor for the development of ischemic events, since inflammation is linked to alterations in coagulation [ 6, 8].
Atherosclerotic stenoses of extracranial carotid arteries are the major risk factor for the development of ischemic stroke.
Multiple studies have shown that APOE is an important predicting factor for the development of ischemic stroke [ 46, 64- 66].
In this population, factors inherent to the heart disease can be added to other traditional risk factors for the development of ischemic heart disease in the future.
Thus, further studies on the potential role of SHBG in the development of ischemic heart disease (IHD) should be performed.
A comparison of the two groups showed no significant difference in the development of ischemic injury (one patient in each group).
Complement activation has been shown to be an important event in the development of ischemic AKI in mice.
It is well known that the inflammatory response plays an important role also in the development of ischemic heart disease.
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