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Cardiomyocyte death is one major factor in the development of heart dysfunction, thus, understanding its mechanism may help with the prevention and treatment of this disease.
Elevated blood cholesterol, which can result in atherosclerotic plaques, is a major risk factor in the development of heart disease; thereby, research has focused on targeting this aspect of disease pathophysiology.
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Patients with heart failure often have pre-existing hypertension and hypertrophy, recognized as independent risk factors in the development of heart failure.
Loss of cardiomyocytes and their replacement with reactive fibrosis are important causative factors in the development of heart failure.
Increased afterload results in 'pathological' cardiac hypertrophy, the most important risk factor for the development of heart failure.
The heartbeat pattern of e-cigarette users indicated elevated levels of adrenaline, also called epinephrine, which is a risk factor for the development of heart disease.
Insufficient sleep is a risk factor for the development of heart disease, high blood pressure, diabetes mellitus, obesity, depression and earlier death.
Previous studies have defined that obesity is a risk factor for the development of heart failure.
Type 2 diabetes mellitus is an independent risk factor for the development of heart failure.
The Framingham Heart Study also showed that increased plasma Hcy levels are a risk factor for the development of heart failure [ 20].
Type 2 diabetes itself is also a risk factor for the development of heart disease and stroke.
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